2 studies on Cortical excitability mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
**Intranasal delivery of just 2 ng of epitalon** produced robust, multi-phase cortical activation in anesthetized rats, establishing that this pineal tetrapeptide can reach and directly modulate neocortical neurons wi…
**Intranasal delivery of epitalon at nanogram doses is sufficient to directly excite neocortical neurons**, suggesting the peptide is bioactive in the CNS at very low concentrations and can bypass the blood-brain barr…